High-Protein Pepperoni Stromboli

Featured in: Family Classics

This hearty Italian-American classic combines protein-rich lean ground beef with spicy pepperoni and melted mozzarella, all wrapped in golden pizza dough. Ready in under an hour, this stromboli delivers 37g of protein per serving while offering the satisfying flavors of a stuffed pizza in portable form.

Updated on Sun, 08 Feb 2026 14:32:00 GMT
Golden-brown Baked High-Protein Pepperoni Stromboli sliced into thick, cheesy servings on a rustic wooden board, ready to enjoy. Pin It
Golden-brown Baked High-Protein Pepperoni Stromboli sliced into thick, cheesy servings on a rustic wooden board, ready to enjoy. | rapidtongs.com

There's something about the smell of pepperoni and melted mozzarella baking in the oven that instantly transforms a quiet afternoon into a moment of anticipation. My kitchen filled with that savory aroma one weeknight when I decided to stop ordering stromboli and actually make one at home, and I haven't looked back since. What started as a simple craving turned into this golden, protein-packed roll that somehow feels more impressive than it actually is to create. The best part? It's ready in under an hour, and your family will think you've spent all day in the kitchen.

I made this for my sister's birthday dinner, and watching her face light up when she bit into that warm, gooey center reminded me why I love cooking for people. She kept asking if it was homemade, skeptical that something this delicious could come from my oven and not a pizzeria. It became the dish everyone requested at gatherings after that, which felt like the highest compliment.

Ingredients

  • Pizza dough (1 pound): The foundation of everything, and honestly, using store-bought saves you time without sacrificing quality; just let it come to room temperature before rolling so it stretches without fighting back.
  • Lean ground beef (8 oz): This is where your protein comes from, and browning it properly means it stays moist inside the roll instead of drying out during baking.
  • Pepperoni slices (2 oz): Those little circles of spice are essential, and a slight overlap as you layer them ensures every bite gets that familiar, satisfying kick.
  • Shredded mozzarella cheese (2 cups): Go for whole milk if you can because it melts into those dreamy pockets of creaminess that make stromboli worth eating.
  • Grated Parmesan cheese (1/2 cup): This adds a sharp, salty depth that prevents the whole thing from feeling one-note.
  • Chopped onions (1/2 cup) and minced garlic (2 cloves): These aromatics cook down into the beef filling and create layers of flavor that taste like someone spent hours on this.
  • Dried Italian herbs (1 tsp): A simple shortcut that tastes authentic, blending oregano and basil into every bite of filling.
  • Crushed red pepper flakes (1/4 tsp, optional): I always include these because the subtle heat balances the richness of the cheese beautifully.
  • Egg wash (1 beaten egg): This creates that gorgeous golden-brown exterior that catches the light and makes the whole thing look bakery-quality.
  • Olive oil (1 tbsp) and marinara sauce: The oil helps everything cook evenly, and the marinara on the side lets people dip and customize their experience.

Instructions

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Heat your oven and prep your workspace:
Set the oven to 400°F and line your baking sheet with parchment paper so the bottom gets crispy without sticking. This small step saves you from frustration later.
Build the flavor base:
Heat olive oil in a skillet over medium heat and sauté the onions until they turn translucent and soft, about 2 to 3 minutes. Add the garlic, stir for just 30 seconds until fragrant, then push everything to the side.
Brown the beef properly:
Add your ground beef to the skillet and break it apart with a wooden spoon as it cooks, making sure no large chunks remain. Season generously with salt, pepper, Italian herbs, and red pepper flakes, cooking until it's completely browned with no pink remaining, then let it cool briefly.
Shape your canvas:
On a lightly floured surface, use a rolling pin to stretch the pizza dough into a large rectangle roughly 12 by 16 inches. Don't stress about perfection; rustic is beautiful here.
Layer with intention:
Spread the cooled beef mixture evenly over the dough, leaving a 1-inch border around all sides so you have room to seal it. This border is your secret to a stromboli that doesn't leak filling everywhere.
Add the signature fillings:
Layer the pepperoni slices across the beef, then sprinkle both mozzarella and Parmesan cheeses evenly over top. The combination of these two cheeses is what makes it taste restaurant-quality.
Roll with confidence:
Starting from one long edge, roll the dough tightly toward you like you're making a sleeping bag, then pinch the seam and the ends firmly to seal everything inside. This sealing step prevents the filling from escaping during baking.
Position for baking:
Transfer the stromboli seam-side down onto your prepared baking sheet, brush the entire top with beaten egg, and use a sharp knife to make 3 to 4 diagonal slits for steam to escape. This egg wash is what gives you that shine.
Bake until golden:
Bake for 25 to 30 minutes until the top is deep golden brown and the filling is cooked through. A thermometer should read 160°F at the thickest part if you want to be certain.
Rest before cutting:
Let it sit for 5 minutes out of the oven so the filling sets and doesn't spill everywhere when you slice. This patience pays off in every bite.
Slice and serve:
Cut into portions and serve alongside warm marinara sauce for dipping.
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Vacuum seal ingredients and leftovers to keep food fresh longer and simplify meal prep.
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Freshly baked Baked High-Protein Pepperoni Stromboli with a golden crust sits beside a small bowl of warm marinara dip. Pin It
Freshly baked Baked High-Protein Pepperoni Stromboli with a golden crust sits beside a small bowl of warm marinara dip. | rapidtongs.com

My daughter asked if we could make this every week, which felt like winning the parent lottery, considering she usually picks at my cooking. Sharing that moment, watching her happily eat something wholesome and satisfying that she helped assemble, reminded me that the best recipes are the ones that bring people to the table.

Why Ground Beef Matters Here

Using lean ground beef keeps this dish from becoming heavy, and when you season it properly in the skillet, it becomes far more flavorful than it would be if it were just mixed raw into the dough. The browning process creates those little caramelized bits that taste like umami and anchor the whole filling. I've experimented with turkey as a lighter option, and while it works, beef has a richness that makes stromboli feel like a real occasion.

The Two-Cheese Strategy

Most homemade stromboli recipes use only mozzarella, but adding Parmesan elevates everything by bringing a salty, nutty sharpness that prevents the filling from tasting one-dimensional. The mozzarella provides that stretchy, melty comfort you crave, while the Parmesan adds personality and depth. Together, they create something that tastes more intentional than casual, even though you're doing almost nothing differently.

Variations and Make-Ahead Tips

This base recipe is endlessly adaptable to what's in your fridge or what you're in the mood for on any given night. Sautéed spinach, roasted red peppers, or mushrooms add nutrition and flavor without changing the technique at all. If you want to prep ahead, you can assemble the entire stromboli earlier in the day, cover it with plastic wrap, and bake it straight from the refrigerator, adding just 5 extra minutes to the cooking time.

  • Try mixing cooked Italian sausage with the ground beef for a spicier version with even more depth.
  • Vegetarians can skip the meat entirely and load up on roasted vegetables and cheeses, making it equally satisfying.
  • Fresh basil scattered on top right after baking adds a brightness that makes people ask for your secret.
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Close-up of a steamy slice of Baked High-Protein Pepperoni Stromboli revealing layers of savory ground beef and melted mozzarella. Pin It
Close-up of a steamy slice of Baked High-Protein Pepperoni Stromboli revealing layers of savory ground beef and melted mozzarella. | rapidtongs.com

This stromboli has become the recipe I reach for when I want something that feels special but doesn't require a culinary degree or six hours in the kitchen. It's proof that simple, thoughtful cooking can satisfy both hunger and the soul.

Your Questions Answered

Can I make this stromboli ahead of time?

Yes, you can assemble the stromboli up to 24 hours in advance and refrigerate it unbaked. Let it come to room temperature for 20 minutes before brushing with egg and baking.

What can I serve with pepperoni stromboli?

Warm marinara sauce is classic for dipping. Pair with a crisp green salad, garlic bread, or roasted vegetables. A light Italian red wine complements the rich flavors beautifully.

How do I store and reheat leftovers?

Store cooled slices in an airtight container in the refrigerator for up to 4 days. Reheat in a 350°F oven for 10 minutes or microwave individual slices for 1-2 minutes until heated through.

Can I freeze this stromboli?

Wrap the baked and cooled stromboli tightly in plastic and foil, then freeze for up to 3 months. Thaw overnight in the refrigerator and reheat at 350°F for 15-20 minutes.

Why make slits in the top before baking?

The diagonal slits allow steam to escape during baking, preventing the stromboli from developing air pockets or bursting. They also create an attractive pattern and help the crust bake evenly.

Can I use different meats or make it vegetarian?

Absolutely. Substitute turkey, chicken, or Italian sausage for the beef. For a vegetarian version, use sautéed mushrooms, spinach, bell peppers, and extra cheese instead of meat.

High-Protein Pepperoni Stromboli

Protein-packed Italian-style stuffed dough with beef, pepperoni, and melted cheese

Prep Duration
20 minutes
Cook Duration
30 minutes
Complete Time
50 minutes
Created by Lily Turner


Skill Level Needed Medium

Cuisine Style Italian-American

Makes 4 Portions

Diet Preferences None specified

What You'll Need

Dough

01 1 pound pizza dough

Meat & Cheese Filling

01 8 ounces lean ground beef
02 2 ounces pepperoni slices
03 2 cups shredded mozzarella cheese
04 1/2 cup grated Parmesan cheese

Vegetables & Seasoning

01 1/2 cup chopped onions
02 2 cloves garlic, minced
03 1 teaspoon dried Italian herbs
04 1/4 teaspoon crushed red pepper flakes
05 Salt and black pepper to taste

Extras

01 1 large egg, beaten
02 1 tablespoon olive oil
03 Marinara sauce for serving

How-To Steps

Step 01

Preheat and Prepare: Preheat oven to 400°F. Line a baking sheet with parchment paper.

Step 02

Sauté Aromatics: Heat olive oil in a large skillet over medium heat. Sauté onions for 2 to 3 minutes until translucent. Add minced garlic and cook for 30 seconds until fragrant.

Step 03

Brown Beef Filling: Add ground beef to the skillet, breaking it into small pieces as it cooks. Season with salt, pepper, dried Italian herbs, and red pepper flakes. Cook until beef is browned and no longer pink, approximately 5 to 7 minutes. Remove from heat and cool for 5 minutes.

Step 04

Roll Dough: On a lightly floured work surface, roll pizza dough into a large rectangle approximately 12 by 16 inches.

Step 05

Spread Filling: Evenly distribute the cooked beef mixture over the dough, leaving a 1-inch border on all sides.

Step 06

Layer Toppings: Arrange pepperoni slices over the beef layer. Evenly sprinkle shredded mozzarella and grated Parmesan cheese on top.

Step 07

Roll and Seal: Starting from a long edge, tightly roll the dough into a cylinder, pinching the ends and seam to seal completely.

Step 08

Place on Baking Sheet: Position the stromboli seam-side down on the prepared baking sheet. Brush the entire top surface with beaten egg wash.

Step 09

Vent the Stromboli: Using a sharp knife, make 3 to 4 diagonal slits across the top to allow steam to escape during baking.

Step 10

Bake: Bake for 25 to 30 minutes until the top is golden brown and the stromboli is cooked through. Remove from oven and let rest for 5 minutes.

Step 11

Slice and Serve: Slice the stromboli into portions and serve immediately with warm marinara sauce on the side.

What You'll Need

  • Large skillet
  • Rolling pin
  • Baking sheet
  • Parchment paper
  • Pastry brush
  • Sharp knife

Allergy Alerts

Always review every item for allergens. If unsure, talk to a healthcare expert.
  • Contains wheat and gluten from pizza dough
  • Contains dairy from mozzarella and Parmesan cheese
  • Contains eggs from egg wash
  • Pepperoni may contain additional allergens; verify product labels for individual sensitivities

Nutrition Info (per serving)

Use these numbers as a helpful reference, not as personal health advice.
  • Calorie Count: 520
  • Fat Content: 25 g
  • Carbohydrates: 35 g
  • Protein Amount: 37 g